Prism Peptides
Retatrutide 30mg
Retatrutide 30mg
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🔴 IMPORTANT: Read Before Proceeding With Dosing
For research and educational use only.
Always follow correct reconstitution and injection practices to avoid avoidable side effects.
⚡ RETATRUTIDE
Triple Agonist • Rapid Fat Loss • Metabolic Optimization
Retatrutide is the most comprehensive metabolic peptide currently under study, activating three key hormonal pathways involved in fat loss, metabolic balance, and energy regulation:
- GLP-1 → appetite suppression, insulin regulation
- GIP → glucose control, fat metabolism
- Glucagon → energy expenditure, lipolysis (fat breakdown)
By combining GLP-1, GIP, and glucagon agonism, Retatrutide advances beyond Semaglutide and Tirzepatide, delivering faster and deeper fat loss with broad systemic benefits.
⚙️ Mechanism of Action
| Pathway | Effect | Outcome |
|---|---|---|
| GLP-1 | Slows gastric emptying, reduces appetite | Eat less, feel fuller |
| GIP | Enhances insulin release, improves glucose tolerance | Better carb handling & energy balance |
| Glucagon | Increases metabolic rate, triggers fat oxidation | Faster fat loss, higher energy use |
📊 Clinical Effectiveness
| Peptide | Receptor Targets | Average Weight Loss | Duration |
|---|---|---|---|
| Semaglutide | GLP-1 | 17% | 68 weeks |
| Tirzepatide | GLP-1 + GIP | 24.7% | 72 weeks |
| Retatrutide | GLP-1 + GIP + Glucagon | 17.5% | 24 weeks |
| 26.2% | 48 weeks |
➡️ Retatrutide currently shows the most rapid and sustained fat loss in clinical studies.
✨ Additional Benefits
- Anti-inflammatory: may support rheumatoid arthritis & IBD
- Collagen support: improves tone, elasticity & skin tightening post-weight loss
- Wound healing: supports tissue recovery after injury
- Angiogenesis: promotes new blood vessel growth → better circulation
- Muscle regeneration: activates satellite cells for recovery & repair
🧪 Emerging Therapeutic Applications
(under investigation — research evolving)
| Category | Potential Benefit |
|---|---|
| Cardiovascular | Improved cholesterol, hypertension & inflammation markers |
| Liver | Promising for NAFLD reversal |
| Neurological | Parkinson’s / Alzheimer’s research |
| Sleep & Addiction | Sleep apnea & substance use disorder studies |
⚠️ Possible Side Effects
Common (mild–moderate, dose-dependent):
- Nausea, vomiting
- Constipation or diarrhea
- Headache, indigestion
- Abdominal discomfort
- Reduced appetite
- Dehydration
Rare but Serious:
- Gallbladder disease
- Pancreatitis
- Intestinal blockages
- Gastroparesis (delayed stomach emptying)Kidney strain linked to dehydration
➡️ Side effects typically improve with hydration, slower titration, and nighttime dosing.
💡 Side-Effect Management
| Issue | Strategy |
|---|---|
| Nausea | Dose at night, smaller meals |
| Constipation | Fiber + electrolytes |
| Appetite too low | Prioritize protein first |
| Strong adverse effects | Increase dose more slowly |
| High GI sensitivity | Avoid heavy & greasy foods |
🚫 Contraindications — Do NOT Use If:
- Pregnant or nursing
- Severe GI disorders (Crohn’s, IBD)Advanced liver disease or chronic kidney disease
- Active or family history of thyroid cancer / MEN-2
- Hypersensitivity to peptide-based medications
💉 General Dosing Guidelines
- Inject once weekly — same day every week
- Remain at each dose ≥ 4 weeks
- Increase only when progress plateaus
- Start dose depends on prior GLP use:
| Experience | Starting Dose |
|---|---|
| Never used GLP-1/GIP | 2 mg weekly |
| Used GLP previously & escalated at least once | 4 mg weekly |
➡️ If still losing weight at your current dose → stay there until needed.
💉 Reconstitution & Dosing Protocols
Subcutaneous Administration — Dose Once Weekly (every 7 days)
Stay minimum 4 weeks per dose level before increasing.
If still losing at your current dose → you may stay longer before titrating up.
🔹 How to Determine Your Starting Dose
- New to GLP-based peptides: start 2 mg weekly
- Previously on a GLP and increased dose at least once: start 4 mg weekly
Dose at night if experiencing nausea, indigestion, or dizziness.
✅ Retatrutide Reconstitution & Unit Conversion
Quick Conversion Rule:
Units needed = (Desired mg ÷ mg-per-unit)
🧪 Retatrutide — 10 mg vial
Mix with: 1 mL (100 units) BAC water
Final concentration: 1 mg = 10 units
| Dose | Units |
|---|---|
| 2 mg | 20 units |
| 4 mg | 40 units |
| 6 mg | 60 units |
| 8 mg | 80 units |
| 10 mg | 100 units |
🧪 Retatrutide — 20 mg vial
Mix with: 2 mL (200 units) BAC water
Final concentration: 1 mg = 10 units (same as 10 mg vial — just double volume)
| Dose | Units |
|---|---|
| 2 mg | 20 units |
| 4 mg | 40 units |
| 6 mg | 60 units |
| 8 mg | 80 units |
| 10 mg | 100 units |
| 12 mg | 120 units |
| 15 mg | 150 units |
| 20 mg | 200 units |
✔ This format keeps the same units-per-mg as the 10 mg vial, making titration easier
✔ Best choice if you want longer use between reconstitution cycles
✔ Recommended for users reacting strongly at higher concentration (less sting)
🧪 Retatrutide — 30 mg vial
Mix with: 2.5 mL (250 units) BAC water
Final concentration: 1 mg ≈ 8.3 units
| Dose | Units |
|---|---|
| 2 mg | 16 units |
| 4 mg | 34 units |
| 6 mg | 50 units |
| 8 mg | 66 units |
| 10 mg | 84 units |
| 12 mg | 100 units |
🧪 Retatrutide — 40 mg vial
Mix with: 3 mL (300 units) BAC water
Final concentration: 1 mg = 7.5 units
| Dose | Units |
|---|---|
| 2 mg | 15 units |
| 4 mg | 30 units |
| 6 mg | 45 units |
| 8 mg | 60 units |
| 10 mg | 75 units |
| 12 mg | 90 units |
⭐ Which Concentration Should I Choose?
| Vial | BAC Added | Concentration | Why Choose It |
|---|---|---|---|
| 10 mg | 1 mL | Most concentrated | Smallest injection volume |
| 20 mg | 2 mL | Medium ← Recommended | Easiest math, smoother comfort |
| 30 mg | 2.5 mL | Less concentrated | Longer-term vial usage |
| 40 mg | 3 mL | Least concentrated | Best for sensitive injectors |
This chart uses Retatrutide 20 mg reconstituted with 2 mL BAC water
(1 mg = 10 units) — the easiest math for weekly use.
💉 Retatrutide Weekly Titration — 30 mg Vial
Reconstitution: Mix 30 mg with 2.5 mL (250 units) BAC water
Final concentration: 1 mg ≈ 8.3 units
Administration: Once every 7 days — same day each week
Progression Rule: Stay ≥ 4 weeks per step before increasing
🧮 Unit Conversion (Quick Reference)
| Dose (mg) | Units (approx.) |
|---|---|
| 2 mg | 16–17 units |
| 4 mg | 33–34 units |
| 6 mg | 50 units |
| 8 mg | 66–67 units |
| 10 mg | 83–84 units |
| 12 mg | 100 units |
| 15 mg | 125 units (optional high phase) |
Round to the nearest whole unit for easier drawing.
📅 Retatrutide Titration Schedule (30 mg / 2.5 mL)
Choose the track that matches your GLP experience.
If losing steadily → do NOT increase yet.
🟢 Beginner Track (No Prior GLP Use)
| Weeks | Weekly Dose | Units |
|---|---|---|
| 1–4 | 2 mg | 16–17 u |
| 5–8 | 4 mg | 33–34 u |
| 9–12 | 6 mg | 50 u |
| 13–16 | 8 mg | 66–67 u |
| 17+ | 10 mg | 83–84 u (only if needed) |
⚡ Intermediate Track (Previously on GLP & escalated)
| Weeks | Weekly Dose | Units |
|---|---|---|
| 1–4 | 4 mg | 33–34 u |
| 5–8 | 6 mg | 50 u |
| 9–12 | 8 mg | 66–67 u |
| 13–16 | 10 mg | 83–84 u |
🚀 Advanced Track (High Tolerance / Faster Cut)
| Weeks | Weekly Dose | Units |
|---|---|---|
| 1–4 | 4 mg | 33–34 u |
| 5–8 | 6 mg | 50 u |
| 9–12 | 8 mg | 66–67 u |
| 13–16 | 10 mg | 83–84 u |
| 17–20 | 12 mg | 100 u (optional) |
| 21+ | 15 mg | 125 u (rarely needed — use only if plateau) |
Most users never need above 8–10 mg if still progressing.
More dose = more side effects, not always better results.
🧠 Side-Effect Adaptive Adjustment
Use this if symptoms flare:
| Symptom | Adjustment |
|---|---|
| Nausea / vomiting | Dose at night → reduce 2 mg → increase hydration |
| Constipation | Add fiber & electrolytes → do NOT increase dose until resolved |
| Fatigue | Increase protein intake → 1–2 g/kg/day |
| Plateau | Stay at current dose 2–4 more weeks before stepping up |
| Injection discomfort | Add 20–50 units of BAC water to syringe to dilute |
🔗 Retatrutide 30 mg Titration + Stacking Recommendations
Reconstitution: 30 mg + 2.5 mL BAC → 1 mg ≈ 8.3 units
Dosing: once weekly, same day, ≥ 4 weeks per step before increasing
🟢 Beginner Track — No Prior GLP Use
| Weeks | Weekly Dose | Units | Recommended Stacks | Purpose |
|---|---|---|---|---|
| 1–4 | 2 mg | 16–17u | BPC-157, Semax, GHK-Cu topical | Gut comfort, mood clarity, skin support while appetite adjusts |
| 5–8 | 4 mg | 33–34u | AOD-9604, Glutathione, BPC-157 | Accelerate fat loss, support liver, stabilize digestion |
| 9–12 | 6 mg | 50u | Tesamorelin, AOD-9604, CJC-1295/Ipamorelin | Visceral fat reduction + muscle preservation |
| 13–16 | 8 mg | 66–67u | Cagrilintide, Tesamorelin, GHK-Cu | Break hunger resistance, support recomposition & skin tightness |
| 17+ | 10 mg (if needed) | 83–84u | TB-500, BPC-157, Glutathione | Joint protection during rapid loss, recovery, antioxidant support |
⚡ Intermediate Track — Previous GLP Use
| Weeks | Weekly Dose | Units | Recommended Stacks | Purpose |
|---|---|---|---|---|
| 1–4 | 4 mg | 33–34u | AOD-9604, GHK-Cu topical | Faster fat mobilization + skin elasticity |
| 5–8 | 6 mg | 50u | Tesamorelin, BPC-157, Glutathione | Muscle retention + gut comfort + detox |
| 9–12 | 8 mg | 66–67u | Cagrilintide, AOD-9604, GHK-Cu | Appetite reinforcement + burn + tighten |
| 13–16 | 10 mg | 83–84u | Tesamorelin, CJC-1295/Ipamorelin | Lean mass preservation + recovery |
🚀 Advanced Track — High Tolerance / Cutting
| Weeks | Weekly Dose | Units | Recommended Stacks | Purpose |
|---|---|---|---|---|
| 1–4 | 4 mg | 33–34u | AOD-9604 + GHK-Cu | Begin fat mobilization & skin prep |
| 5–8 | 6 mg | 50u | Tesamorelin + TB-500 | Muscle retention + inflammation control |
| 9–12 | 8 mg | 66–67u | Cagrilintide + AOD-9604 | Maximum satiety + bodyfat loss |
| 13–16 | 10 mg | 83–84u | Tesamorelin + CJC-1295/Ipamorelin + Glutathione | Deep cut: muscle support + GH synergy + detox |
| 17–20 (optional) | 12 mg | 100u | GHK-Cu topical + TB-500 + BPC-157 | Recovery, skin tightening, joint stability |
🎯 Why These Stacks Work
| Target | Stack | Effect |
|---|---|---|
| Break Plateau | Cagrilintide | Reinforces hunger control, reduces cravings |
| Avoid Muscle Loss | Tesamorelin + CJC/Ipamorelin | Upregulates GH/IGF-1 repair pathways |
| Skin Tightening | GHK-Cu topical/injectable | Collagen & elastin support during fat loss |
| Deep Fat Burn | AOD-9604 | Lipolysis without affecting appetite |
| Recovery Support | BPC-157 + TB-500 | Tissue repair + joint integrity |
| Liver / Detox | Glutathione | Helps during caloric deficit + fat breakdown |
🧠 Quick Recommendations
- If appetite returns → add Cagrilintide
- If nausea increases → stay at the same dose longer
- If muscle loss risk rises → add Tesamorelin or CJC/Ipamorelin
- If loose skin appears → add GHK-Cu topical
- If joints ache → add TB-500 + BPC-157