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Prism Peptides

Retatrutide 20mg

Retatrutide 20mg

₱2,500.00 PHP
₱2,500.00 PHP
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🔴 IMPORTANT: Read Before Proceeding With Dosing

For research and educational use only.
Always follow correct reconstitution and injection practices to avoid avoidable side effects.

⚡ RETATRUTIDE

Triple Agonist • Rapid Fat Loss • Metabolic Optimization

Retatrutide is the most comprehensive metabolic peptide currently under study, activating three key hormonal pathways involved in fat loss, metabolic balance, and energy regulation:

  • GLP-1 → appetite suppression, insulin regulation
  • GIP → glucose control, fat metabolism
  • Glucagon → energy expenditure, lipolysis (fat breakdown)

By combining GLP-1, GIP, and glucagon agonism, Retatrutide advances beyond Semaglutide and Tirzepatide, delivering faster and deeper fat loss with broad systemic benefits.

⚙️ Mechanism of Action

Pathway Effect Outcome
GLP-1 Slows gastric emptying, reduces appetite Eat less, feel fuller
GIP Enhances insulin release, improves glucose tolerance Better carb handling & energy balance
Glucagon Increases metabolic rate, triggers fat oxidation Faster fat loss, higher energy use

📊 Clinical Effectiveness

Peptide Receptor Targets Average Weight Loss Duration
Semaglutide GLP-1 17% 68 weeks
Tirzepatide GLP-1 + GIP 24.7% 72 weeks
Retatrutide GLP-1 + GIP + Glucagon 17.5% 24 weeks
26.2% 48 weeks

➡️ Retatrutide currently shows the most rapid and sustained fat loss in clinical studies.

✨ Additional Benefits

  • Anti-inflammatory: may support rheumatoid arthritis & IBD
  • Collagen support: improves tone, elasticity & skin tightening post-weight loss
  • Wound healing: supports tissue recovery after injury
  • Angiogenesis: promotes new blood vessel growth → better circulation
  • Muscle regeneration: activates satellite cells for recovery & repair

🧪 Emerging Therapeutic Applications

(under investigation — research evolving)

Category Potential Benefit
Cardiovascular Improved cholesterol, hypertension & inflammation markers
Liver Promising for NAFLD reversal
Neurological Parkinson’s / Alzheimer’s research
Sleep & Addiction Sleep apnea & substance use disorder studies

⚠️ Possible Side Effects

Common (mild–moderate, dose-dependent):

  • Nausea, vomiting
  • Constipation or diarrhea
  • Headache, indigestion
  • Abdominal discomfort
  • Reduced appetite
  • Dehydration

Rare but Serious:

  • Gallbladder disease
  • Pancreatitis
  • Intestinal blockages
  • Gastroparesis (delayed stomach emptying)Kidney strain linked to dehydration

➡️ Side effects typically improve with hydration, slower titration, and nighttime dosing.

💡 Side-Effect Management

Issue Strategy
Nausea Dose at night, smaller meals
Constipation Fiber + electrolytes
Appetite too low Prioritize protein first
Strong adverse effects Increase dose more slowly
High GI sensitivity Avoid heavy & greasy foods

🚫 Contraindications — Do NOT Use If:

  • Pregnant or nursing
  • Severe GI disorders (Crohn’s, IBD)Advanced liver disease or chronic kidney disease
  • Active or family history of thyroid cancer / MEN-2
  • Hypersensitivity to peptide-based medications

💉 General Dosing Guidelines

  • Inject once weekly — same day every week
  • Remain at each dose ≥ 4 weeks
  • Increase only when progress plateaus
  • Start dose depends on prior GLP use:
Experience Starting Dose
Never used GLP-1/GIP 2 mg weekly
Used GLP previously & escalated at least once 4 mg weekly

➡️ If still losing weight at your current dose → stay there until needed.

💉 Reconstitution & Dosing Protocols

Subcutaneous Administration — Dose Once Weekly (every 7 days)
Stay minimum 4 weeks per dose level before increasing.
If still losing at your current dose → you may stay longer before titrating up.

🔹 How to Determine Your Starting Dose

  • New to GLP-based peptides: start 2 mg weekly
  • Previously on a GLP and increased dose at least once: start 4 mg weekly

Dose at night if experiencing nausea, indigestion, or dizziness.

✅ Retatrutide Reconstitution & Unit Conversion

Quick Conversion Rule:
Units needed = (Desired mg ÷ mg-per-unit)

🧪 Retatrutide — 10 mg vial

Mix with: 1 mL (100 units) BAC water
Final concentration: 1 mg = 10 units

Dose Units
2 mg 20 units
4 mg 40 units
6 mg 60 units
8 mg 80 units
10 mg 100 units

🧪 Retatrutide — 20 mg vial 

Mix with: 2 mL (200 units) BAC water
Final concentration: 1 mg = 10 units (same as 10 mg vial — just double volume)

Dose Units
2 mg 20 units
4 mg 40 units
6 mg 60 units
8 mg 80 units
10 mg 100 units
12 mg 120 units
15 mg 150 units
20 mg 200 units

✔ This format keeps the same units-per-mg as the 10 mg vial, making titration easier
✔ Best choice if you want longer use between reconstitution cycles
✔ Recommended for users reacting strongly at higher concentration (less sting)

🧪 Retatrutide — 30 mg vial

Mix with: 2.5 mL (250 units) BAC water
Final concentration: 1 mg ≈ 8.3 units

Dose Units
2 mg 16 units
4 mg 34 units
6 mg 50 units
8 mg 66 units
10 mg 84 units
12 mg 100 units

🧪 Retatrutide — 40 mg vial

Mix with: 3 mL (300 units) BAC water
Final concentration: 1 mg = 7.5 units

Dose Units
2 mg 15 units
4 mg 30 units
6 mg 45 units
8 mg 60 units
10 mg 75 units
12 mg 90 units

⭐ Which Concentration Should I Choose?

Vial BAC Added Concentration Why Choose It
10 mg 1 mL Most concentrated Smallest injection volume
20 mg 2 mL Medium ← Recommended Easiest math, smoother comfort
30 mg 2.5 mL Less concentrated Longer-term vial usage
40 mg 3 mL Least concentrated Best for sensitive injectors

This chart uses Retatrutide 20 mg reconstituted with 2 mL BAC water
(1 mg = 10 units) — the easiest math for weekly use.

💉 Retatrutide Weekly Titration Schedule

Dose once every 7 days — stay on each step ≥ 4 weeks
➡️ If still losing weight at your current dose → remain until plateau
➡️ Increase only when needed for continued progress

🔰 Beginner Schedule (No prior GLP use)

(slow & gentle — lowest side-effect risk)

Weeks Weekly Dose Units Notes
1–4 2 mg 20 units Initial adaptation / appetite suppression begins
5–8 4 mg 40 units Increased satiety, fat loss ramps
9–12 6 mg 60 units Moderate therapeutic range
13–16 8 mg 80 units Strong appetite control
17+ 10 mg 100 units Go here only if needed

➡️ Most users do not need to exceed 8 mg if progressing steadily.

⚡ Intermediate Schedule (Prior GLP exposure)

(for users who already tolerated Semaglutide/Tirzepatide)

Weeks Weekly Dose Units Notes
1–4 4 mg 40 units Easier transition from prior GLP
5–8 6 mg 60 units Metabolic acceleration
9–12 8 mg 80 units Max appetite blocking & fat oxidation
13–16 10 mg 100 units For plateaus or stalled progress

➡️ If nausea / indigestion returns → drop back one level.

🚀 Advanced Schedule (High tolerance, aggressive cut)

(ONLY if side effects are minimal and researcher experience is high)

Weeks Weekly Dose Units Notes
1–4 4 mg 40 units Base activation
5–8 6 mg 60 units Rapid fat loss onset
9–12 8 mg 80 units Main working phase
13–16 10 mg 100 units Push phase — expect stronger appetite suppression
17–20 12 mg 120 units Short-term max phase (not required for all)**

➡️ 12 mg should only be used if absolutely necessary.
➡️ Most clinical benefit occurs between 6–10 mg.

🧠 Side-Effect Adaptive Adjustment

Use this if symptoms flare:

Symptom Adjustment
Nausea / vomiting Dose at night → reduce 2 mg → increase hydration
Constipation Add fiber & electrolytes → do NOT increase dose until resolved
Fatigue Increase protein intake → 1–2 g/kg/day
Plateau Stay at current dose 2–4 more weeks before stepping up
Injection discomfort Add 20–50 units of BAC water to syringe to dilute

💡 Stacking Suggestions by Phase

Phase Stack Why
Weeks 1–4 BPC-157 GI relief, gut adaptation
Weeks 5–8 AOD-9604 Increases fat mobilization
Weeks 9–12 Tesamorelin Visceral fat + muscle preservation
Weeks 12+ GHK-Cu Skin tightening after fat loss

🔥 Cagrilintide can be added at any stage for enhanced satiety + hunger control
(dose on separate day — slow titration)

🎯 Quick Reference

  • 1 mg = 10 units
  • Increase only after 4+ weeks at each doseHigher dose ≠ always better — progress > power
  • If losing steadily, don’t increase
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