🔴 IMPORTANT: Read This Before Proceeding With Dosing

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c)

MOTS-C is a mitochondrial-encoded peptide that plays a critical role in metabolic regulation, insulin sensitivity, and mitochondrial health. It is naturally upregulated during exercise and is therefore considered an exercise mimetic—a compound that mimics the beneficial physiological effects of physical activity.

MOTS-C levels decline significantly with age, contributing to insulin resistance, metabolic dysfunction, mitochondrial stress, and reduced NAD+ activity. Supplementation is commonly researched in individuals with obesity, metabolic syndrome, diabetes, cardiovascular disease, and age-related decline.

⚙️ Mechanism of Action (Simplified)

• Improves glucose uptake in skeletal muscle
• Regulates mitochondrial fission and fusion
• Reduces mitochondrial oxidative stress
• Supports metabolic flexibility
• Interacts with nuclear genes involved in aging and metabolic disease
• Acts downstream of exercise-induced signaling pathways

✨ Benefits

Supports weight loss & fat oxidation

Increases metabolic rate

Reduces visceral & liver fat

Improves insulin sensitivity

Protects against metabolic disorders (e.g., NASH)

Enhances physical performance & endurance

Improves muscle function

• Cardiovascular protection & reduced vascular calcification
• Neuroprotective (may delay Alzheimer’s progression)
• Protects against macular degeneration
• Anti-inflammatory & immunoregulatory effects
• Mitigates chemotherapy-induced side effects
• Inhibits inflammatory painAntimicrobial activity (including MRSA)
• Improves survival in severe infections / sepsisLongevity & healthy aging support

⚠️ Possible Side Effects

• Injection-site redness, swelling, or itching
• Headache
• Mild GI discomfort

Rare: oxidative stress or tissue fatigue with overuse.
These are typically dose-dependent.

🔗 Synergistic Peptides

• SS-31 ⭐ Highly recommended prior to MOTS-C
• Humanin
• Frag 176-292
• Tesofensine

Best practice: Cycle SS-31 first to prime mitochondrial membranes, then follow with MOTS-C.

💧 RECONSTITUTION & DOSING PROTOCOLS

🧪 MOTS-C — 10 mg Vial

Reconstitution:

• Mix with 0.5 mL (50 units) bacteriostatic water
• Concentration: 1 mg = 5 units
• Administration: Subcutaneous

🟢 STANDARD PROTOCOLS

✅ 20-Day Protocol — 20 mg total

• Dose: 5 mg (25 units)
• Frequency: Once every 5 days
• Injections: 4 total
• Total used: 20 mg

Vials Needed

• 10 mg vials: 2 vials

✅ 30-Day Protocol — 40 mg total

• Dose: 10 mg (50 units)
• Frequency: Once weekly
• Injections: 4 total
• Total used: 40 mg

Vials Needed

• 40 mg vial: 1 vial ✅ (best choice)

🔴 MAXIMUM PROTOCOLS

⚡ 4-Week Intensive Cycle — 60 mg total

• Dose: 5 mg (25 units)
• Frequency: 3× per week
• Total used: 60 mg

Vials Needed

• 10 mg vials: 6 vials
• 40 mg vials: 2 vials (80 mg total → buffer)

⚡ 6-Week Intensive Cycle — 90 mg total

• Dose: 5 mg (25 units)
• Frequency: 3× per week
• Total used: 90 mg

Vials Needed

• 10 mg vials: 9 vials
• 40 mg vials: 3 vials (120 mg total → buffer)

🚀 10-Week Protocol — 100 mg total

• Dose: 10 mg (50 units)
• Frequency: Once weekly
• Injections: 10 total
• Total used: 100 mg

Vials Needed

• 10 mg vials: 10 vials
• 40 mg vials: 3 vials (120 mg total → buffer)

📊 Quick Summary Table

📌 Practical Notes

• 40 mg vials are more efficient for anything beyond light cycles
• Extra buffer accounts for priming loss, dead space, and spillage
• Store reconstituted vials refrigerated and use within 30–45 days

🔁 Cycling Guidelines

• Typical cycles: 20 days to 10 weeks
• Do not run continuously year-round
• Allow at least 8–12 weeks off between aggressive cycles
• SS-31 should precede each MOTS-C cycle when possible

🔗 Stacking Suggestions

💎 Why Choose MOTS-C?

• True mitochondrial peptide, not synthetic hormone mimicry
• Addresses aging at the cellular energy level
• Ideal for users who can’t exercise intensely
• Powerful metabolic and longevity support
• Complements weight-loss peptides without appetite suppression

🧊 Storage

• Refrigerate after reconstitution
• Use within 30–45 days